Ischemia Care’s proprietary RNA expression testing is built upon significant peer reviewed published data, as well as other abstracts, presentations, white papers, etc. Please see below for a listing of select materials. For references or data not listed, please contact the company for further information.
RNA expression differentiates large artery and cardioembolic stroke: A pilot analysis from the BASE trial. Jauch, E.C. 2018 AHA/ASA International Stroke Conference oral abstract presentation.
Potential Clinical Impacts of the ISCDX Test in Standardizing Diagnosis of Stroke, clinical panel discussion at a 2018 International Stroke Conference company sponsored satellite meeting.
Biomarkers of Acute Stroke Etiology (BASE) Study Methodology, Jauch, E.C., Barreto, A.D., Broderick, J.P. et al. Transl. Stroke Res. (2017) 8: 424.
Cryptogenic stroke patient stratification using the ISCDX classifier algorithm: A pilot analysis from the BASE trial, presentation at a 2017 International Stroke Conference company sponsored satellite meeting.
RNA Gene Expression Identifies Cardioembolic Causes of Ischemic Stroke: A pilot analysis from the BASE trial. Jauch, E.C. et al, 2017 preliminary BASE data abstract.
Biomarkers of Acute Stroke Etiology (BASE) NCT02014896: An ongoing clinical trial currently enrolling to validate a blood test for cause of ischemic stroke, E. Jauch, MUSC; J. O’Neill / A. Venkat, Allegheny Health Network; T. Schoonover, Kettering; W. Hicks, Riverside; F. Peacock, Baylor Med Ctr; et al. 2017 AHA/ASA International Stroke Conference poster presentation.
Biomarkers of Acute Stroke Etiology (BASE) NCT02014896 Overview. 2016 AHA/ASA International Stroke Conference poster presentation.
2012 Lab to lab validation of previously peer reviewed stroke data using RNA expression, a pilot analysis comparing academic discovery data sets with a separate "analytical validation" in an Ischemia Care CLIA laboratory to demonstrate lab to lab consistency of clinically derived data.
Tang Y, et al: Blood genomic responses differ after stroke, seizures, gypoglycemia, and hypoxia: blood genomic fingerprints of disease. Ann Neurol 2001, 50(6):699-707.
Tang Y, et al: Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J Cereb Blood Flow Metab 2006, 26(8):1089-1102 Epub 2006 Jan 1084.
Xu H, et al: Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic stroke. J Cereb Blood Flow Metab 2008, 28(7):1320-1328.
Jickling GC, et al: Signatures of cardioembolic and large-vessel ischemic stroke. Ann Neurol. 2010 Nov;68(5):681-92.
Stamova B, et al: Gene expression profiling of blood for the prediction of ischemic stroke. Stroke. 2010 Oct/41(10):2171-7.Epub 2010 Aug 26.