© 2019 by Superior Computer Services, Inc.

Science

Ischemia Care’s proprietary RNA expression testing is built upon significant peer reviewed published data, as well as other abstracts, presentations, white papers, etc. Please see below for a listing of select materials. For references or data not listed, please contact the company for further information.

​RNA expression differentiates large artery and cardioembolic stroke: A pilot analysis from the BASE trial. Jauch, E.C. 2018 AHA/ASA International Stroke Conference oral abstract presentation.

Potential Clinical Impacts of the ISCDX Test in Standardizing Diagnosis of Stroke, clinical panel discussion at a 2018 International Stroke Conference company sponsored satellite meeting.

Biomarkers of Acute Stroke Etiology (BASE) Study Methodology, Jauch, E.C., Barreto, A.D., Broderick, J.P. et al. Transl. Stroke Res. (2017) 8: 424. https://doi.org/10.1007/s12975-017-0537-3.

Cryptogenic stroke patient stratification using the ISCDX classifier algorithm: A pilot analysis from the BASE trial, presentation at a 2017 International Stroke Conference company sponsored satellite meeting.

RNA Gene Expression Identifies Cardioembolic Causes of Ischemic Stroke: A pilot analysis from the BASE trial. Jauch, E.C. et al, 2017 preliminary BASE data abstract.

Biomarkers of Acute Stroke Etiology (BASE) NCT02014896: An ongoing clinical trial currently enrolling to validate a blood test for cause of ischemic stroke, E. Jauch, MUSC; J. O’Neill / A. Venkat, Allegheny Health Network; T. Schoonover, Kettering; W. Hicks, Riverside; F. Peacock, Baylor Med Ctr; et al. 2017 AHA/ASA International Stroke Conference poster presentation.

Biomarkers of Acute Stroke Etiology (BASE) NCT02014896 Overview. 2016 AHA/ASA International Stroke Conference poster presentation.

2012 Lab to lab validation of previously peer reviewed stroke data using RNA expression, a pilot analysis comparing academic discovery data sets with a separate "analytical validation" in an Ischemia Care CLIA laboratory to demonstrate lab to lab consistency of clinically derived data.

Tang Y, et al: Blood genomic responses differ after stroke, seizures, gypoglycemia, and hypoxia: blood genomic fingerprints of disease. Ann Neurol 2001, 50(6):699-707.

Tang Y, et al: Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J Cereb Blood Flow Metab 2006, 26(8):1089-1102 Epub 2006 Jan 1084.

Xu H, et al: Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic stroke. J Cereb Blood Flow Metab 2008, 28(7):1320-1328.

Jickling GC, et al: Signatures of cardioembolic and large-vessel ischemic stroke. Ann Neurol. 2010 Nov;68(5):681-92.

Stamova B, et al: Gene expression profiling of blood for the prediction of ischemic stroke. Stroke. 2010 Oct/41(10):2171-7.Epub 2010 Aug 26.

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